Modifications of sperm cells to function

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Posttranslational Modifications in Spermatozoa and Effects on Male Fertility and Sperm Viability.

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Spermatozoon - Wikipedia

Spermatozoa acquire their fertilizing ability and forward motility properties during epididymal transit. Our knowledge of gamete physiology is based on studies conducted in laboratory and domestic species; our knowledge of these processes in humans is limited. Medical indications for assisted reproductive technologies ART have progressed to include male infertility. Surgical procedures allow collection of spermatozoa from all along the human excurrent ducts, and the former have been used with some success in reproductive medicine. This has raised questions over the role of the epididymis in human sperm physiology. To reanalyze what we now know about epididymal physiology in humans and to assess the relevance of laboratory animal models for understanding human physiology and the pathophysiology of the epididymis.
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Sperm cells are gametes sex cells that are produced in the testicular organ gonad of male human beings and animals. Like the female gamete Oocyte , sperm cells carry a total of 23 chromosomes that are a result of a process known as meiosis. In both animals and human beings, among many other organisms, these cells are involved in the sexual mode of reproduction which involves the interaction of male and female gametes. The general morphology of sperm cells consists of the following parts:. Before looking at the structure and function of sperm cells, it is important to understand the process involved in their production spermatogenesis.
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Spermatogenesis is a complex and highly regulated process. The ability of spermatozoa to perform its function depends on multiple physiological and genetic factors that are not fully understood. Notably, due to lack of transcriptional and translational activity in spermatozoa, posttranslational modifications PTMs play key roles in determining their viability.
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